#COMPREHENSIVE META ANALYSIS ODDS RATIO SERIES#

A confidence interval for the Mantel-Haenszel odds ratio in StatsDirect is calculated using the Robins, Breslow and Greenland variance formula ( Robins et al., 1986) or by the method of Sato (1990) if the estimate of the odds ratio can not be determined. The Mantel-Haenszel method is used to estimate the pooled odds ratio for all strata, assuming a fixed effects model:ДЄlternative methods, such Woolf and inverse variance, can be used to estimate the pooled odds ratio with fixed effects but the Mantel-Haenszel method is generally the most robust. If the вЂ™try exactвЂ™ option is not selected then the logit (Woolf) interval is given instead. With very large numbers these calculations can take an appreciable amount of time. Sample estimate of the odds ratio = (ad)/(bc)ДЇor each table, the observed odds ratio is displayed with an exact confidence interval ( Martin and Austin, 1991 Sahai and Kurshid, 1996). Exact methods are used here in addition to conventional approximations.ДЇor a single stratum odds ratio is estimated as follows: This StatsDirect function examines the odds ratio for each stratum (a single fourfold table) and for the group of studies as a whole.

#COMPREHENSIVE META ANALYSIS ODDS RATIO SERIES#

Meta-analysis is used to investigate the combination or interaction of a group of independent studies, for example a series of fourfold tables from similar studies conducted at different centres. The Mantel-Haenszel method provides a pooled odds ratio across the strata of fourfold tables. Stratification of this kind is sometimes used to reduce confounding.

The separation of data into different tables or strata represents a sub-grouping, e.g. healed or not healed) can by represented by arranging the observed counts into fourfold (2 by 2) tables. Further trials are necessary to evaluate the efficacy and tolerability versus other medications.Mantel-Haenszel Test and Odds Ratio Meta-analysisД¬ase-control studies of dichotomous outcomes (e.g. Our results suggest that aripiprazole is effective and safe in treating bipolar mania. Aripiprazole was also associated with higher levels of high density lipoprotein, lower dropout rates, but no difference in extrapyramidal symptoms in the maintenance phase versus a placebo or in comparison with other medications (haloperidol or lithium). Aripiprazole was associated with lower relapse rates in bipolar mania when used in combination versus a placebo in maintenance therapy (odds ratio: 0.522, p < 0.029). в€’0.299, p=0.001) and psychosis (Hedges' g: в€’0.296, p < 0.001) in the acute mania state, but did not improve depressive symptoms (Hedges' g: в€’0.127, p =0.054) in the acute depressive state. Compared to a placebo, aripiprazole improved acute mania (Hedges' g: A total of 20 RCTs met the eligibility criteria, including two which investigated the efficacy of aripiprazole versus haloperidol (aripiprazole =340 haloperidol =337), three which compared aripiprazole versus lithium (aripiprazole =208 lithium =212), and 15 with multiple comparisons of aripiprazole versus a placebo (aripiprazole =1923 placebo =1499). Randomized controlled trials (RCTs) of people with BD who received aripiprazole were included. Two authors conducted systematic searches of PubMed and ScienceDirect from inception until May 14th, 2017. therefore we conducted this comprehensive meta-analysis to investigate the efficacy and safety profile of aripiprazole in treating BD. Numerous studies have investigated aripiprazole as a treatment for bipolar disorder (BD). Progress in Neuro-Psychopharmacology & Biological Psychiatry, v. Efficacy, safety and tolerability of aripiprazole in bipolar disorder : an updated systematic review and meta-analysis of randomized controlled trials. Progress in Neuropsychopharmacology & Biological Psychiatry Please use this identifier to cite or link to this item:Д®fficacy, safety and tolerability of aripiprazole in bipolar disorder : an updated systematic review and meta-analysis of randomized controlled trials

Comprehensive meta analysis odds ratio